Dr. Lue was trained as an urologist in China and a basic researcher in Harbor-UCLA and joined faculty in 2001. The major focus of his research has been the genetic and hormonal regulation of spermatogenesis. He has demonstrated that testicular hyperthermia enhances the suppression of spermatogenesis induced by testosterone implants in both rats and monkeys. He has been studying the functional roles of progesterone receptors in the testes and hypothesizes that progestins mediated through the progesterone receptors may have direct inhibitory actions on sperm production. He has characterized the XXY mouse model for investigating the most common sex chromosome aneuploidy in men–Klinefelter's syndrome. He has been studying the cellular and molecular mechanisms of gonadal and neurobehavioral defects in XXY mice. He also has an interest in spermatogonial stem cell research. Techniques include PCR, real time RT-PCR, Southern blot, Northern blot, Western blot, 2D gel electrophoresis, MALDI-TOF, in situ hybridization, immunohistochemistry, gene microarray, karyotype, laser microdissection, confocal microscopy, and germ cell transplantation.