Dr. Lee is a Pediatric Endocrinologist who joined the faculty in 1986. He is Acting Division Chief of Pediatric Endocrinology and Director of the BioMedical Mass Spectrometry Facility. His primary research area is the application of stable isotopes and mass spectrometry to nutrition and metabolic studies. In the past few years, his laboratory has developed methods of interpreting distribution of mass isotopomers through the Krebs cycle. Such methods are now being applied to study lactate metabolism and gluconeogenesis in man, including glucoregulatory disturbances in children and infants. Recently, he has developed methods to study lipogenesis using deuterated water and mass isotopomer analysis. Such methods are being used in studies of abnormal lipid metabolism in diabetes. In the coming years, he plans to study the effect of nutrients on gene-expression using LC/MS methods in animal models of diabetes and obesity.